Method of stimulating TLR9-activated immune response
US10337017B2 · kind B2 · utility
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Key dates
| Filing date | Dec 29, 2017 |
| Grant date | Jul 2, 2019 |
| Priority date | — |
| Expiry date | Dec 29, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/17
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of stimulating a TLR9-activated immune response or enhancing a TLR9-activated immune response to an antigen is disclosed herein. TLR9 is the cellular receptor for CpG-ODN, and current developed CpG-ODN has low activity to rabbit TLR9. Here, the method of stimulating TLR9-activated immune response by administering an effective amount of immunogenic composition comprising an antigen and a CpG-ODN comprising GACGTT or AACGTT motif was demonstrated to have potent immunostimulatory activity to rabbit TLR9, and capable of boosting a less toxic and potent antibody response in rabbits.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.