Kanamycin compound, kanamycin-producing Streptomyces species bacterium, and method of producing kanamycin
US10337044B2 · kind B2 · utility
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11Claims
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Key dates
| Filing date | Aug 20, 2015 |
| Grant date | Jul 2, 2019 |
| Priority date | — |
| Expiry date | Oct 16, 2036 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Vectors expressing kanA-kanB-kanK and other kanamycin production-related genes, Streptomyces species recombinant bacteria transformed with the vectors, a method of producing kanamycin antibiotics by the bacteria, and a new kanamycin compound produced by the bacterium are provided. With the use of the recombinant bacteria of the present invention, the direct fermentative biosynthesis of amikacin and tobramycin as semi-synthetic kanamycins is possible, and the yield of kanamycin B as a precursor of the semi-synthetic kanamycin is improved.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.