Compounds and conjugates for identifying and separating post-translationally modified analytes
US10338037B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 17, 2016 |
| Grant date | Jul 2, 2019 |
| Priority date | — |
| Expiry date | Nov 11, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/067
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed herein are embodiments of compounds, conjugates, and devices, such as columns comprising such compounds and/or conjugates, that can be used to identify, separate, and quantify post-translationally modified analytes. The disclosed compounds and conjugates can be used to discriminate between analytes, such as peptides, having different post-translation modifications, such as methylations, phosphorylations, acetylations, citrullinations, hydroxylations, nitrosylations, ADP-ribosylations, glycosylations, propionylations, butyrylations, crotonylations, 2-hydroxyisobutyrylations, malonylations, succinylations, formylations, ubiquitinations, neddylations, proline cis-trans isomerizations. In particular disclosed embodiments, the compounds and conjugates can be used to separate peptides having different degrees of methylation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.