Patent · US Active

Measurement of protein expression using reagents with barcoded oligonucleotide sequences

US10338066B2 · kind B2 · utility

62Cited by
127References
15Claims
0Family size

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Inventors

Key dates

Filing dateMay 30, 2018
Grant dateJul 2, 2019
Priority date—
Expiry dateMay 30, 2038

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG16H20/13
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

Some embodiments disclosed herein provide a plurality of compositions each comprising a protein binding reagent conjugated with an oligonucleotide. The oligonucleotide comprises a unique identifier for the protein binding reagent it is conjugated with, and the protein binding reagent is capable of specifically binding to a protein target. Further disclosed are methods and kits for quantitative analysis of a plurality of protein targets in a sample and for simultaneous quantitative analysis of protein and nucleic acid targets in a sample. Also disclosed herein are systems and methods for preparing a labeled biomolecule reagent, including a labeled biomolecule agent comprising a protein binding reagent conjugated with an oligonucleotide.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.