Method of encapsulating a nucleic acid in a lipid nanoparticle host
US10342761B2 · kind B2 · utility
1Cited by
21References
17Claims
0Family size
Assignee
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Key dates
| Filing date | Jul 10, 2015 |
| Grant date | Jul 9, 2019 |
| Priority date | — |
| Expiry date | Jul 10, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Encapsulated nucleic acid nanoparticles of uniformly small particle size are produced by intersecting one or more nucleic acid streams with one or more lipid streams. The encapsulated nucleic acid nanoparticles include a nucleic acid encapsulated within a lipid nanoparticle host. Uniformly small particle sizes are obtained by intersecting an aqueous nucleic acid stream and a stream of lipids in organic solvent at high linear velocities and with total organic solvent concentrations less than 33%.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.