Patent · US Active

Tetrahydro-isohumulone derivatives, methods of making and using

US10343977B2 · kind B2 · utility

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1Claims

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Assignee

KINDEX PHARMACEUTICALS, INC. · US

Inventors

Veera Konda · Bellevue, US
Jan Urban · San Diego, US
Anuradha Desai · Gig Harbor, US
Clinton J. Dahlberg · Port Orchard, US
Brian J. Carroll · Gig Harbor, US

Key dates

Filing date	Nov 27, 2017
Grant date	Jul 9, 2019
Priority date	—
Expiry date	Nov 27, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C2601/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present application provides novel tetrahydro-isohumulone (THIAA) derivatives and substantially enantiomerically pure compositions and pharmaceutical formulations thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPARγ, inhibit inflammation, and treat conditions associated with inflammation and conditions responsive to PPARγ modulation such as diabetes.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.