Modulators of the eIF2alpha pathway

US10343981B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Peter Walter · San Francisco, US
• Carmela Sidrauski · Saratoga, US
• Diego Acosta Alvear · San Francisco, US
• Michelle Arkin · San Francisco, US
• Christopher Gerard Wilson · Berkeley, US
• Kean-Hooi Ang · Singapore, SG
• Brian Hearn · San Francisco, US
• Punitha Vedantham · Burlingame, US
• Adam Renslo · Oakland, US
• Mervyn Maze · London, GB
• Susana Vacas · San Francisco, US

Key dates

• Filing date: Jun 5, 2017
• Grant date: Jul 9, 2019
• Expiry date: Jun 5, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2α phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.