Quaternary heteroatom containing compounds

US10343996B2 · kind B2 · utility

Assignee

• CALIFORNIA INSTITUTE OF TECHNOLOGY · US

Inventors

• Brian M. Stoltz · San Marino, US
• Scott C. Virgil · Pasadena, US
• David E. White · Wayne, US
• Taiga Yurino · Kyoto, JP
• Yiyang Liu · Pasadena, US
• Douglas C. Behenna · San Juan Capistrano, US
• Douglas R. Duquette · Glencoe, US
• Christian Eidamshaus · Mannheim, DE

Key dates

• Filing date: Jul 30, 2018
• Grant date: Jul 9, 2019
• Expiry date: Jul 30, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D309/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.