Gene encoding FHB1 resistance to Fusarium Head Blight disease and uses thereof

US10344297B2 · kind B2 · utility

Assignees

• Kansas State University Research Foundation · US
• Regents of the University of Minnesota · US

Inventors

• Bikram Singh Gill · Manhattan, US
• Nidhi Rawat · Greenbelt, US
• Eduard Akhunov · Manhattan, US
• Michael Pumphrey · Pullman, US
• James A. Anderson · Woodbury, US
• Sixin Liu · Purcellville, US

Key dates

• Filing date: May 29, 2015
• Grant date: Jul 9, 2019
• Expiry date: May 29, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/415
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A protein conferring resistance to Fusarium Head Blight disease (FHB) is described, along with the DNA sequence of the corresponding gene and mRNA copy (cDNA). The cDNA of Fhb1 gene can be used to produce genetically-modified plants having increased resistance to FHB, particularly in wheat, barley and other plants affected by the disease. The protein has antifungal properties and inhibits fungal growth, thereby providing a means for reducing DON toxin in grains. Conserved functional domains are identified in the protein. Genetically-modified plants having increased resistance FHB are also described, along with methods for producing such genetically-modified plants.