Patent · US Active

Activated formylglycine-generating enzymes and methods of producing and using the same

US10344311B2 · kind B2 · utility

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1References

24Claims

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Inventors

David Rabuka · Kensington, US
Gregory W. deHart · Corona, US
Patrick Holder · Oakland, US
Jeanne Baker · Redwood City, US

Key dates

Filing date	Jan 4, 2018
Grant date	Jul 9, 2019
Priority date	—
Expiry date	Jan 4, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y108/99
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present disclosure provides activated formylglycine-generating enzymes (FGE), methods of producing activated FGE, and their use in methods of producing a protein comprising a formylglycine (FGly) residue. The methods of producing activated FGE, as well as methods of use of activated FGE in producing FGly-containing proteins, include both cell-based and cell-free methods. Compositions and kits that find use, e.g., in practicing the methods of the present disclosure are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.