Glatiramer acetate response biomarker mRNA potency assay
US10344330B2 · kind B2 · utility
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11References
50Claims
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Key dates
| Filing date | Mar 12, 2014 |
| Grant date | Jul 9, 2019 |
| Priority date | — |
| Expiry date | Sep 2, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention describes assays for determining the potency of a test lot of glatiramer acetate (GA) by quantitating and comparing the levels of mRNA response biomarkers produced in mouse T-cells in response to stimulation with the test lot or a reference standard lot of GA, wherein the T-cells are obtained from mice immunized with the test lot or the reference standard lot of GA. Methods for identifying mRNA response biomarkers useful in the assays of the invention also are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.