Nanopore device for reversible ion and molecule sensing or migration
US10345260B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 6, 2015 |
| Grant date | Jul 9, 2019 |
| Priority date | — |
| Expiry date | Oct 18, 2035 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01L2300/0896
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed are methods and devices for detection of ion migration and binding, utilizing a nanopipette adapted for use in an electrochemical sensing circuit. The nanopipette may be functionalized on its interior bore with metal chelators for binding and sensing metal ions or other specific binding molecules such as boronic acid for binding and sensing glucose. Such a functionalized nanopipette is comprised in an electrical sensor that detects when the nanopipette selectively and reversibly binds ions or small molecules. Also disclosed is a nanoreactor, comprising a nanopipette, for controlling precipitation in aqueous solutions by voltage-directed ion migration, wherein ions may be directed out of the interior bore by a repulsing charge in the bore.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.