IGFBP7 for diagnosing diastolic dysfunction

US10345315B2 · kind B2 · utility

Assignee

• Roche Diagnostics Operations, Inc. · US

Inventors

• Johann Karl · Peißenberg, DE
• Ursula-Henrike Wienhues-Thelen · Krailling, DE
• Dirk Block · Bichl, DE
• Christian Zaugg · Rheinfelden, CH
• Hans-Peter Brunner · Münchenstein, CH
• James Januzzi · Wellesley, US
• Andre Ziegler · Läufelfingen, CH
• Julian Braz · Greenwood, US
• Thomas Dieterle · Freiburg (Elbe), DE
• Edelgard Kaiser · Chur, CH

Key dates

• Filing date: Sep 23, 2016
• Grant date: Jul 9, 2019
• Expiry date: Sep 23, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/325
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Disclosed herein is a method for diagnosing and/or grading diastolic dysfunction or at least one structural or functional abnormality associated with diastolic dysfunction. The method involves measuring the level of IGFBP7 (Insulin like growth factor binding protein 7) and, optionally, the level of at least one further marker in a patient suffering from heart failure, and comparing the level to a reference level. Also disclosed is a method of monitoring diastolic function in a patient suffering from heart failure, and kits and devices for performing the method.