Patent · US Active

2′ fluoro-modified RNAs as immunostimulators

US10350158B2 · kind B2 · utility

3Cited by

1References

17Claims

0Family size

Assignee

Duke University · US

Inventors

Jaewoo Lee · Seoul, KR
Johannes Urban · Munich, DE
Bruce A. Sullenger · Durham, US

Key dates

Filing date	Jan 2, 2018
Grant date	Jul 16, 2019
Priority date	—
Expiry date	Jan 2, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2320/32
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Methods of inhibiting the growth of cells or inducing cell death by contacting the cells with or introducing into the cells a composition including a 5′ triphosphate, 2′ fluoro-modified pyrimidine non-linear single stranded RNA at least 17 nucleotides long with a least 3 base pairings or a 5′ triphosphate, 2′ fluoro-modified double stranded RNA at least 17 base pairs long in an amount effective to inhibit cell growth, induce cell death or induce cytokine production by the cells. The methods also include administration of the compositions to a subject. The subject may have a proliferative disorder or infectious disease and administration of the compositions provided herein may treat the disorder or disease.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.