Pharmaceutical composition of MEK inhibitor and preparation method thereof

US10350198B2 · kind B2 · utility

Assignee

• Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · CN

Inventors

• Xiongxiong He · 安丰镇, CN
• Ping Dong · 安丰镇, CN
• Jiahui Cai · Tangxia, CN
• Xifeng Lu · Lianyungang, CN
• Jiao Xu · Lianyungang, CN
• Bo Jiang · Ningbo City, CN
• Zhenxue Deng · Lianyungang, CN
• Shanshan Sui · Lianyungang, CN

Key dates

• Filing date: May 27, 2016
• Grant date: Jul 16, 2019
• Expiry date: May 27, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/048
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application provides a pharmaceutical composition comprising 6-(2-chloro-4-iodophenylamino)-N-(2-hydroxyethoxy)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridine-7-carboxamide or a pharmaceutically acceptable salt, a binder, a surface stabilizer and a dispersant, wherein the pharmaceutical composition can be dispersed in water to form a pharmaceutical suspension having a median particle size, X50, of 0.5 μm to 4.0 μm. Also disclosed are a preparation method thereof and the use thereof for treating cancers.