Patent · US Active

Isoquinolidinobenzodiazepine (IQB)-1(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimers

US10350218B2 · kind B2 · utility

0Cited by

4References

11Claims

0Family size

Assignee

Cellerant Therapeutics, Inc. · US

Inventors

Jagath R. Junutula · Fremont, US
Sean Wesley Smith · Wantage, US
Dmitry Borkin · Uniontown, US
Sylvia Degrado · Scotch Plains, US
Sanjeevani Ghone · Monmouth Junction, US

Key dates

Filing date	Feb 23, 2018
Grant date	Jul 16, 2019
Priority date	—
Expiry date	Feb 23, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/73
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are isoquinolidinobenzodiazepine (IQB)-1(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimers, antibody-drug conjugates comprising them and methods of use for killing cells and treating disease.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.