System and method for capturing and analyzing cells

US10350601B2 · kind B2 · utility

Assignee

• Celsee Diagnostics, Inc. · US

Inventors

• Kalyan Handique · Ann Arbor, US
• Kyle Gleason · Hercules, US
• Austin Payne · Ann Arbor, US
• Priyadarshini Gogoi · Plymouth, US
• Christopher Siemer · Ypsilanti, US
• Yi Zhou · 安丰镇, CN
• Saedeh Javdani Sepehri · Ypsilanti, US

Key dates

• Filing date: Oct 12, 2017
• Grant date: Jul 16, 2019
• Expiry date: Dec 11, 2037

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01L2400/0683
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A system for isolating cells in at least one of single-cell format and single-cluster format, comprising a reservoir, including a reservoir inlet and a reservoir outlet, configured to receive a biological sample and to receive at least one fluid, a manifold configured to receive and deliver the biological sample and the at least one fluid from the reservoir into a biological sample substrate, the manifold comprising a broad surface comprising a central region configured to receive the biological sample substrate, a set of openings configured to enable fluid flow transmission across the biological sample substrate, a manifold inlet configured to transmit flow from the reservoir the first subset of openings, a manifold outlet configured at a downstream end of the broad surface and coupled to the second subset of openings, the manifold outlet configured to transmit waste fluid from the manifold.