Dosage forms with desired release profiles and methods of designing and making thereof

US10350822B1 · kind B1 · utility

Assignee

• Triastek, Inc. · CN

Inventors

• Feihuang DENG · Nanjing, CN
• Xiaoling Li · Dublin, US
• Senping CHENG · Nanjing, CN

Key dates

• Filing date: Jul 30, 2018
• Grant date: Jul 16, 2019
• Expiry date: Jul 30, 2038

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B33Y80/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In some aspects, the present disclosure provides dosage forms, such as oral drug dosage forms, configured to provide a desired release profile, the dosage forms comprising a multi-layered structure comprising a plurality of layers of a first erodible material admixed with a compound (e.g., a drug) or a reagent, wherein the first erodible material is embedded in a second material not admixed with the compound (e.g., the drug) or the reagent. In other aspects, the present disclosure provides methods of designing, such as obtaining a thickness and/or surface area of a layer comprising an erodible material admixed with a compound (e.g., a drug) or a reagent, and/or amount of the compound (e.g., the drug) or the reagent admixed in the erodible material, and methods of making, such as three-dimensional printing, dosage forms configured to provide desired release profiles.