Patent · US Active

Polypeptides, peptides, and proteins functionalized by alkylation of thioether groups via ring-opening reactions

US10351591B2 · kind B2 · utility

1Cited by

4References

19Claims

0Family size

Assignee

The Regents of the University of California · US

Inventors

Timothy J. Deming · Summerland, US
Eric G. Gharakhanian · Los Angeles, US

Key dates

Filing date	Mar 21, 2016
Grant date	Jul 16, 2019
Priority date	—
Expiry date	Jun 17, 2036

Classification

Technology area (CPC G)Physics
CPC primaryG01N33/68
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Some embodiments of the invention involve methods for introduction of various functional groups onto polypeptides, peptides and proteins by alkylation of thioether (a.k.a. sulfide) groups by ring opening reactions, creating new compositions of matter that may be useful for medical therapeutic or diagnostic applications. The thioether groups may either be present in the polypeptides, or may be added to polypeptides by chemical modification, such as by alkylation of thiol (sulfhydryl) groups.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.