Methods for making definitive endoderm using at least GDF-8
US10351820B2 · kind B2 · utility
0Cited by
75References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 13, 2017 |
| Grant date | Jul 16, 2019 |
| Priority date | — |
| Expiry date | Aug 22, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/90
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.