Non-invasive functional assessment of coronary artery stenosis including simulation of hyperemia by changing resting microvascular resistance

US10354744B2 · kind B2 · utility

Assignee

• Siemens Healthcare Limited · DE

Inventors

• Puneet Sharma · Rahway, US
• Michael Scheuering · Koblenzer Straße, DE
• Lucian Mihai Itu · Brașov, RO
• Ali Kamen · Skillman, US
• Bogdan Georgescu · Plainsboro, US
• Xudong Zheng · Plainsboro, US
• Huseyin Tek · Princeton, US
• Dorin Comaniciu · Princeton Junction, US
• Dominik Bernhardt · Eschborn, DE
• Fernando Vega-Higuera · Erlangen, DE

Key dates

• Filing date: Nov 4, 2013
• Grant date: Jul 16, 2019
• Expiry date: Mar 18, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B2576/023
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A method and system for non-invasive assessment of coronary artery stenosis is disclosed. Patient-specific anatomical measurements of the coronary arteries are extracted from medical image data of a patient acquired during rest state. Patient-specific rest state boundary conditions of a model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest. Patient-specific rest state boundary conditions of the model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest. Hyperemic blood flow and pressure across at least one stenosis region of the coronary arteries are simulated using the model of coronary circulation and the patient-specific hyperemic boundary conditions. Fractional flow reserve (FFR) is calculated for the at least one stenosis region based on the simulated hyperemic blood flow and pressure.