Pro-drugs of riluzole and their method of use for the treatment of amyotrophic lateral sclerosis
US10357497B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 24, 2013 |
| Grant date | Jul 23, 2019 |
| Priority date | — |
| Expiry date | Jun 24, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/5377
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pharmaceutical compositions of the invention include substituted riluzole pro drugs useful for the treatment of amyotrophic lateral sclerosis (ALS) and related disorders through the release of riluzole, especially to avoid patient to patient variability in first pass, hepatic metabolism promoted by Cyp 1A2. Pro-drugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process. The invention further includes pro-drugs of riluzole useful for the treatment of disease states that can be treated with riluzole through the release of riluzole from a pro-drug agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.