Substituted pyrrolidines as G-protein coupled receptor 43 agonists
US10358416B2 · kind B2 · utility
0Cited by
5References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 20, 2018 |
| Grant date | Jul 23, 2019 |
| Priority date | — |
| Expiry date | Jun 20, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to a process for the preparation of aryl-carbonyl-pyrrolidine carboxylic acid derivative compounds which are useful in treating metabolic diseases, said process consisting of coupling a pyrrolidine ester compound with an aryl carboxylic acid derivative, followed by alkaline or acidic treatment, hydrogenolysis or treatment with a fluoride of the obtained intermediate, to afford novel aryl-carbonyl-pyrrolidine carboxylic acid derivative compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.