DNA binding agents with a minor groove binding tail

US10358439B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Waldemar Priebe · Houston, US
• Liwei Guo · Birmingham, US
• Arkadiusz Kazimierski · Old Bridge, US
• Izabela Fokt · Spring, US
• Charles Conrad · Spring, US
• Timothy Madden · Sugar Land, US

Key dates

• Filing date: Sep 16, 2016
• Grant date: Jul 23, 2019
• Expiry date: Sep 16, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/244
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided herein are compounds which intercalate into the DNA of a cell and are capable of crossing the blood brain barrier of a formula provided herein. Pharmaceutical compositions of the compounds and methods of treating cancer, for example brain, lung, or pancreatic cancer, are also provided herein.