Frequency domain discrimination of tissue proteins
US10359414B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 9, 2016 |
| Grant date | Jul 23, 2019 |
| Priority date | — |
| Expiry date | Jan 30, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/78
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Devices and methods for performing frequency domain (FD) fluorescence lifetime spectroscopy are provided. The devices include a modulated light source, a focusing optical fiber, a detecting optical fiber, and a detector. The methods include focusing sinusoidal modulated incident light from a light source on a biological sample containing a protein, detecting a range of wavelengths of sinusoidal modulated fluorescent light emitted from the protein, determining a phase shift for the modulated fluorescent light, determining an amplitude modulation of the modulated fluorescent light, and determining a fluorescence lifetime of the protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.