Enolase inhibitors and methods of treatment therewith
US10363261B2 · kind B2 · utility
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19Claims
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Key dates
| Filing date | Mar 9, 2016 |
| Grant date | Jul 30, 2019 |
| Priority date | — |
| Expiry date | Mar 9, 2036 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are compounds of the formula (I) wherein the variables R1, R2, R3, R4, X1, X2, Y1, and A1 are as defined herein. Such compounds may be used, for example, for the inhibition of enolase enzymes, including preferential inhibition of one isoenzyme of over one or more of the other isoenzymes. Methods of treatment using these compounds, as well as pharmaceutical compositions thereof, are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.