Modified hepatitis post-transcriptional regulatory elements
US10363269B2 · kind B2 · utility
5Cited by
26References
46Claims
0Family size
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Key dates
| Filing date | Jan 12, 2016 |
| Grant date | Jul 30, 2019 |
| Priority date | — |
| Expiry date | Oct 14, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/48
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are polynucleotides containing a modified PRE having a variant X gene that includes one or more stop codons not present in an unmodified, such as wild-type, hepatitis X gene. Also provided are polynucleotides containing a modified PRE having a variant X gene that includes one or more degradation sequences not present in an unmodified, such as wild-type, hepatitis X gene. The modified PRE can be operably linked to a nucleic acid encoding a recombinant protein. Also provided are expression cassettes, viral vectors and cells containing the polynucleotides, and compositions and methods of use thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.