Insulin mimotopes and methods of using the same

US10363288B2 · kind B2 · utility

Assignees

• National Jewish Health · US
• The Regents of the University of Colorado, a Body Corporate · US

Inventors

• Aaron Michels · Aurora, US
• John Kappler · Denver, US
• Peter Gottlieb · Wheelock, US

Key dates

• Filing date: Jan 13, 2016
• Grant date: Jul 30, 2019
• Expiry date: Jan 13, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/042
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods for inhibiting an autoimmune disease by administering to a subject a therapeutically effective amount of a composition that induces conversion of naive T cells into Foxp3+ regulatory T cells to induce immunosuppression in the subject. Methods for detecting in a subject an autoimmune disease or a predisposition to an autoimmune disease, and methods for assessing the efficacy of a therapy for an autoimmune disease, particularly type 1 diabetes.