Mutant OPAA enzyme with increased catalytic efficiency on GP

US10363289B1 · kind B1 · utility

Assignee

• The United States of America as represented by the Secretary of the Army · US

Inventors

• Steven P. Harvey · Timonium, US
• Mark A. Guelta · White Marsh, US
• Leslie R McMahon · Aberdeen, US

Key dates

• Filing date: Dec 13, 2017
• Grant date: Jul 30, 2019
• Expiry date: Dec 13, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y301/01008
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is directed toward mutant, non-wild-type organophosphorus acid anhydrolase enzymes having three site mutations, methods of production, and methods of use to effectively degrade toxic organophosphorus compounds, most preferably GP (2, 2′-dimethylcyclopentyl methylphosphonofluoridate).