Vaccination with anti-tick antigens to control multiple tick species and disease transmission in white-tailed deer and other host animals

US10363292B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary of Agriculture · US
• BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE · US

Inventors

• Andrew Y. Li · Kerrville, US
• Felicito Guerrero · Kerrville, US
• Lane D. Foil · Baton Rouge, US
• Adalberto A. Perez De Leon · Kerrville, US

Key dates

• Filing date: Sep 18, 2017
• Grant date: Jul 30, 2019
• Expiry date: Sep 18, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/58
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions of either the Rm86Texas protein from a Texas outbreak strain of the southern cattle fever tick, Rhipicephalus microplus, or a nucleic acid construct incorporating a nucleic acid sequence encoding this Rm86Texas protein, are effective for eliciting a protective immune response in non-bovine animals. The Rm86Texas protein is immunogenic and can be administered as a protein vaccine, or in the alternative, the nucleic acid construct can be utilized as a DNA vaccine. Induction of the immune response significantly reduces or eliminates the infestation of treated, non-bovine animals with ticks. Moreover, as ticks are vectors of a variety of pathogens, the reduction in the incidence of tick infestation afforded by the vaccines may concurrently reduce the incidence of diseases caused by these pathogens in susceptible animals.