Nanoscale imaging of proteins and nucleic acids via expansion microscopy
US10364457B2 · kind B2 · utility
49Cited by
4References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 5, 2016 |
| Grant date | Jul 30, 2019 |
| Priority date | — |
| Expiry date | Aug 18, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2001/364
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention enables in situ genomic and transcriptomic assessment of nucleic acids to be conducted in biological specimens that have been physically expanded. The invention leverages the techniques for expansion microscopy (ExM) to provide new methods for in situ genomic and transcriptomic assessment of nucleic in a new process referred to herein as “expansion fluorescent in situ hybridization” (ExFISH).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.