Tumor suppressor REC8 as a biomarker for gastric cancer
US10364471B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | May 19, 2017 |
| Grant date | Jul 30, 2019 |
| Priority date | — |
| Expiry date | Jul 16, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/50
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the REC8 gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating gastric cancer by increasing REC8 gene expression or activity. Lastly, a highly sensitive and accurate detection method is provided for rapid determination of REC8 gene methylation status.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.