Attenuated reoviruses for selection of cell populations
US10369171B2 · kind B2 · utility
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28References
21Claims
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Assignee
Inventors
Key dates
| Filing date | Mar 12, 2008 |
| Grant date | Aug 6, 2019 |
| Priority date | — |
| Expiry date | Jan 29, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2720/12032
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods for killing neoplastic cells, such as ras-activated cancerous cells, in vitro. In particular embodiments, an attenuated reovirus (e.g., a reovirus lacking a wild-type S1 gene) may be administered to a mixed cellular composition comprising cancerous cells and stem cells such as adult stem cells and/or hematopoietic stem cells; in these embodiments, the attenuated reovirus may result in killing of the cancerous cells with little or no damage to the healthy stem cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.