Patent · US Active

Allele selective gene editing and uses thereof

US10369232B2 · kind B2 · utility

12Cited by
1References
25Claims
0Family size

Assignee

Inventors

Key dates

Filing dateSep 21, 2016
Grant dateAug 6, 2019
Priority date—
Expiry dateSep 21, 2036

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2320/34
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

This invention encompasses compounds, structures, compositions and methods for therapeutic guide molecules that direct CRISPR gene editing. A guide molecule for directing gene editing can be allele selective, or disease allele selective, and can exhibit reduced off target activity. A guide molecule can be composed of monomers, including UNA monomers, nucleic acid monomers, and modified nucleotides, wherein the compound is targeted to a genomic DNA. The guide molecules of this invention can be used as active ingredients for editing or disrupting a gene in vitro, ex vivo, or in vivo.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.