System and method for robust intensity-modulated proton therapy planning
US10369381B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Sep 2, 2015 |
| Grant date | Aug 6, 2019 |
| Priority date | — |
| Expiry date | May 14, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N2005/1087
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present invention provides a system and method for generating intensity modulated proton therapy plans. The method includes receiving a representation of a subject that includes information related to target and non-target volumes of interest, and computing, using the representation and a proton beam configuration that describes a number of beamlets and their respective arrangement, a dose distribution for each one of a plurality of uncertainty scenarios. The method also includes computing a robustness index for respective locations in the target volumes of interest using the dose distributions, and optimizing an objective function to determine a set of intensity weights for each beamlet in the proton beam configuration, wherein the objective function is based at least in part on deviations of the robustness indices from a prescribed robustness index. The method further includes generating a treatment plan using the determined intensity weights.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.