Inositol nicotinate crystalline form A and preparation method therefor
US10370334B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 21, 2016 |
| Grant date | Aug 6, 2019 |
| Priority date | — |
| Expiry date | Sep 21, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/455
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
Provided are an inositol nicotinate crystalline form A and a preparation method therefor. The X-ray powder diffraction analysis, obtained by using Cu-Kα ray measurement, of the inositol nicotinate crystalline form A has obvious characteristic diffraction peaks at least at 2θ values, expressed in degrees, of 7.05, 7.41, 9.74, 17.80, 19.86, 23.57, 25.48 and 26.20 with an error range of +/−0.2°. The preparation method is one of or a mixed crystallization method of two or more of an evaporation crystallization method, a cooling crystallization method or an anti-solvent crystallization method. The process thereof is simple and easy to operate, and has more selectivity; the inositol nicotinate crystalline form A can be prepared by various methods, and the prepared product has a good crystallization degree and high chemical stability; and the inositol nicotinate crystalline form A prepared by the present method does not have the problem that a residual solvent is out-of-limit.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.