LILRB2 and notch-mediated expansion of hematopoietic precursor cells

US10370643B2 · kind B2 · utility

Assignees

• Fred Hutchinson Cancer Research Center · US
• The Board of Regents of the University of Texas System · US

Inventors

• Irwin D. Bernstein · Seattle, US
• Chengcheng Zhang · Dallas, US
• Mi Deng · Plano, US
• Zhigang Lu · Shanghai, CN
• Junke Zheng · Shanghai, CN

Key dates

• Filing date: May 21, 2015
• Grant date: Aug 6, 2019
• Expiry date: Sep 14, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2501/91
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The current disclosure describes methods of expanding precursor cells for hematopoietic transplantation in subjects. The methods culture precursor cells in media containing an immobilized high molecular weight LILRB2 agonist or an LILRB2 agonist in combination with a Notch agonist. The expanded cells can be used to treat a variety of hematopoietic disorders.