Method of determining risk of 5-fluorouracil toxicity
US10370721B2 · kind B2 · utility
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Key dates
| Filing date | Mar 2, 2015 |
| Grant date | Aug 6, 2019 |
| Priority date | — |
| Expiry date | Mar 2, 2035 |
Classification
- Technology area (CPC —)General
Abstract
The invention provides an assay useful in predicting risk of 5-fluorouracil (FU) toxicity in a subject. The subject may be screened for the presence of at least one TYMS polymorphism and/or at least one DPYD polymorphism. Suitable TYMS and DPYD polymorphisms are provided. The presence of one or more of the polymorphisms indicates an increased risk of developing FU toxicity; a negative result may indicate a decreased risk of developing FU toxicity.
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