Pyrazole pyrimidine derivative and uses thereof

US10376511B2 · kind B2 · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Yinon Ben Neriah · Mevaseret Tsiyon, IL
• Guy Brachya · Jerusalem, IL
• Ido Burstain · Sderot, IL
• Waleed Minzel · Kfar Kanna, IL
• Irit Snir-Alkalay · Mevaseret Tsiyon, IL
• Joseph P. Vacca · Telford, US
• Dansu Li · New York, US

Key dates

• Filing date: Aug 4, 2016
• Grant date: Aug 13, 2019
• Expiry date: Aug 4, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides pyrazole pyrimidine derivatives which inhibit Casein kinase I (CKI) and/or Interleukin-1 receptor-associated kinase 1 (IRAKI) and methods of their manufacture, compositions comprising them and uses thereof in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.