Macrocyclic LRRK2 kinase inhibitors
US10377772B2 · kind B2 · utility
0Cited by
6References
22Claims
0Family size
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Key dates
| Filing date | Sep 17, 2015 |
| Grant date | Aug 13, 2019 |
| Priority date | — |
| Expiry date | Sep 17, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/22
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to novel macrocyclic compounds of formula (I) and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of LRRK2 (Leucine-Rich Repeat Kinase 2). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine or diagnostic agent, in particular for the treatment and/or diagnosis of diseases characterized by LRRK2 kinase activity such as neurological disorders including Parkinson's disease and Alzheimer's disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.