Patent · US Active

Method of targeting mismatched DNA using d8 square planar metal complexes

US10378046B2 · kind B2 · utility

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20Claims

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Assignee

University of Hong Kong · CN

Inventors

Chi-Ming Che · Hong Kong, CN
Sin Ki Fung · Hong Kong, CN
Taotao Zou · Hong Kong, CN

Key dates

Filing date	May 27, 2016
Grant date	Aug 13, 2019
Priority date	—
Expiry date	Mar 8, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2600/156
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Disclosed are methods of using d8 square planar metal complexes containing tridentate π-conjugated ligands and ancillary ligand of N-heterocyclic carbene or di-phosphine ligand to target mismatched DNA. Targeting of mismatched DNA can be revealed by monitoring the differences in emission enhancement of metal complexes toward mismatched DNA and matched DNA; or the gradually heat release from isothermal titration calorimetry (ITC) when complexes bind toward mismatch DNA; or the significant increase in melting temperature of the mismatched DNA after adding complexes.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.