Quinoline derivatives and their use for treating endoplasmic reticulum stress-related diseases and disorders
US10383867B2 · kind B2 · utility
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Key dates
| Filing date | Nov 27, 2016 |
| Grant date | Aug 20, 2019 |
| Priority date | — |
| Expiry date | Nov 27, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are quinolines, e.g., a compound of Formula I, pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of an endoplasmic reticulum stress-caused disease. Also provided herein are methods of their use for reducing endoplasmic reticulum stress and modulating the activity of a sarcoplasmic/endoplasmic reticulum Ca2+ ATPase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.