Dry animal-derived collagen fiber tissue material and preparation method and bioprothesis thereof
US10383978B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 4, 2016 |
| Grant date | Aug 20, 2019 |
| Priority date | — |
| Expiry date | May 4, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L27/60
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A dry animal-derived collagen fiber tissue material and preparation method and bioprosthesis thereof are disclosed. The preparation method includes: 1) rinsing of an animal-derived collagen fiber tissue material that has been treated with a crosslinking agent; 2) immersion of the rinsed tissue material in a non-aqueous alcoholic solution for dehydration; 3) successive immersion of the tissue material that has been dehydrated with the non-aqueous alcoholic solution in saccharide solutions of different gradients of concentrations for gradient dehydration; 4) taking out and drying of the gradient dehydrated tissue material; and 5) hermetic packaging of the dried tissue material and sterilization. The preparation method is simple and allows the use of easily-available low-cost materials, resulting in lower costs. In addition, it can reduce the toxicity caused by a residue of the aldehyde crosslinking agent. The prepared biological tissue material is pliable and tough, less prone to bending or warping, has a water content that can be well controlled and better biocompatibility due to absence of polyhydric alcohol residues.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.