Patent · US Active

Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate

US10385020B2 · kind B2 · utility

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4References

6Claims

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Assignee

Lundbeck Pharmaceuticals Italy S.P.A. · IT

Inventors

Mariano Stivanello · Schio, IT
Florian Huber · Grassau, DE
Antonio Ricci · Birsfelden, CH

Key dates

Filing date	May 11, 2018
Grant date	Aug 20, 2019
Priority date	—
Expiry date	May 11, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D401/12
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Methods are provided for the synthesis of key intermediates for the synthesis of Argatroban monohydrate, ethyl (2R,4R)-1-[(2S)-2-amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate compounded with HCl. Such intermediates are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.