Modified polynucleotides for the production of secreted proteins
US10385106B2 · kind B2 · utility
7Cited by
29References
12Claims
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Key dates
| Filing date | Jan 4, 2016 |
| Grant date | Aug 20, 2019 |
| Priority date | — |
| Expiry date | Jan 4, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure describes compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 5-methoxy-uridines to improve the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, protein half-life and/or modulation of a cell's status function, and/or activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.