Lipidated amide-based insulin prodrugs

US10385107B2 · kind B2 · utility

Assignee

• INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION · US

Inventors

• Richard D. DiMarchi · Carmel, US
• Binbin Kou · Bloomington, US
• Fa Zhang · Montgomery, US
• John Philip Mayer · Boulder, US

Key dates

• Filing date: Sep 23, 2015
• Grant date: Aug 20, 2019
• Expiry date: Sep 23, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half-lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.