Patent · US Active

Mutant glutamate dehydrogenase for the conversion of homoserine into 4-hydroxy-2-ketobutyrate

US10385322B2 · kind B2 · utility

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17Claims

0Family size

Assignee

METABOLIC EXPLORER · FR

Inventors

Zhen Chen
Feng Geng · Hamburg, DE
An-Ping Zeng · Schwäbisch Hall, DE
Wanda Dischert · Champ Parouty, FR
Philippe Soucaille · Deyme, FR

Key dates

Filing date	Oct 2, 2015
Grant date	Aug 20, 2019
Priority date	—
Expiry date	Nov 11, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y104/01004
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention concerns a method for the production of derivatives of 4-hydroxy-2-ketobutyrate chosen among 1,3-propanediol or 2,4-dihydroxybutyrate by culturing a genetically modified microorganism for the production of the desired derivative of 4-hydroxy-2-ketobutyrate, the microorganism further comprising a gene coding for a mutant glutamate dehydrogenase converting by deamination L-homoserine into 4-hydroxy-2-ketobutyrate. The invention also concerns said genetically modified microorganism.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.