Patent · US Active

Method to improve Lactococcus preservation

US10385351B2 · kind B2 · utility

0Cited by

4References

15Claims

0Family size

Assignee

INTREXON ACTOBIOTICS N.V. · BE

Inventors

Erik Remaut · Vinderhoute, BE
Dirk Iserentant · Wijgmaal, BE

Key dates

Filing date	Sep 5, 2017
Grant date	Aug 20, 2019
Priority date	—
Expiry date	Sep 21, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N1/04
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Lactococcus lactis strains with improved preservation characteristics, and improved acid and bile salt tolerance are disclosed. More specifically, a L. lactis strain having a heterologous trehalose-6-phosphate synthase gene and/or a trehalose-6-phosphate phosphatase gene, results in an accumulation of trehalose in the cytoplasm and/or in the cytoplasmic membrane. A L. lactis strain, having an internal trehalose concentration of at least 10 mg per gram cells (w/w) is disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.