Patent · US Active

Production of manool

US10385361B2 · kind B2 · utility

0Cited by

1References

5Claims

0Family size

Assignee

FIRMENICH SA · CH

Inventors

Michel Schalk · Collonges-sous-Salève, FR
Letizia Rocci · Satigny, CH

Key dates

Filing date	Jun 30, 2016
Grant date	Aug 20, 2019
Priority date	—
Expiry date	Jun 30, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y505/01014
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Provided herein are methods of producing (+)-manool comprising: contacting geranylgeranyl diphosphate with an copalyl diphosphate (CPP) synthase to form a (9S, 10S)-copalyl diphosphate wherein the CPP synthase comprises an amino acid sequence having at least 90%, 95%, 98%, 99% and 100% sequence identity to a polypeptide selected from the group consisting of SEQ ID NO: 1 and SEQ ID NO:2; and contacting the CPP with a sclareol synthase enzyme to form (+)-manool.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.