Personalized protease assay to measure protease activity in neoplasms
US10385380B2 · kind B2 · utility
4Cited by
34References
33Claims
0Family size
Assignee
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Key dates
| Filing date | Oct 2, 2015 |
| Grant date | Aug 20, 2019 |
| Priority date | — |
| Expiry date | Dec 19, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/7028
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed herein, the invention pertains to methods and compositions that find use in diagnostic, prognostic and characterization of neoplasia samples based on the ability of a neoplasia sample to cleave a MTS molecule of the present invention. In some embodiments, a MTS molecule disclosed herein has the formula (A-X-B-C), wherein A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and C is a detectable moiety.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.